Journal of Applied Medical Sciences

Treatment of Plane Wart with Topical Adapaline Gel 0.1%: An Open Therapeutic Trial

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•  Abstract

   

  Plane wart is a common dermatological disease with a high rate of spontaneous recovery. Topical adapalene gel 0.1% is a known keratolytic agent with many dermatological uses. To evaluate the efficacy and tolerability of topical adapalene gel 0.1% in the treatment of plane warts. Fifty patients with plane warts consulting the department of Dermatology and Venereology of Al-Kindy Teaching Hospital from August 2011 to April 2012 were enrolled in this opened therapeutic trial. All patients were instructed to apply adapalene gel 0.1% twice daily for 4 weeks duration to be assessed clinically and by digital photograph. If at the end of 4th week no or partial response occurred, the patients were instructed to continue using the treatment and then they were re-evaluated clinically and photographically by the end of 8th week. The response rate was evaluated according to number of lesions. After 4 weeks of treatment, patients who achieved an excellent response were those with 1-10 lesions (8%), while no one with 11- ≥20 achieved an excellent response. The response to treatment in the view of different grades of response and according to no. of lesions were statistically significant (P-value=0.015, p-value=0.031 respectively). After 8 weeks of treatment, the highest figure of excellent response was in those with 1-10 lesions group (30%). The overall response of different grades was statistically significant (P-value=0.014). Whereas response according to number of lesions was not significant (P-value =0.235). According to duration of lesions, after 4 weeks of treatment, patients who achieved an excellent response were mostly those with 1-4 months (8%), while no one with duration of > 4 months achieved an excellent response. After 4 weeks treatment, the response to treatment in the view of different grades was statistically significant (P-value=0.025).The response according to duration of lesions was also significant (P-value=0.003). After 8 weeks of treatment, the highest figure of patients that showed an excellent response was still those with duration of lesions between 1-4 months (28%). On the other hand, patients with duration of lesions more than 8-12 months show the lowest figure (6%). The overall response in different grades was not significant (P-value=0.062). The response according to duration of lesions was also not significant (P-value=0.084). Topical Adapalene gel 0.3% is an effective and safe option of treatment of plane warts.