Journal of Applied Medical Sciences

Long-term Trends and Influencing Factors of Glomerular Filtration Rate

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• Abstract

   

  Purpose: This study assessed chronic kidney disease (CKD) in Pingtung, Taiwan as indicated by the annual changes glomerular filtration rate (GFR) and risk factors of estimated glomerular filtration rate (eGFR).

  Methods: This study utilized longitudinal data analysis to examine the 2011-2013 medical checkup results for adult at a Pingtung hospital. The participants' general information, physical examination results, and blood test results were analyzed. eGFR was calculated via the abbreviated modification of diet in renal disease (aMDRD) formula and used to determine eFGR stages based on the 2002 Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines.

  Results: Data from a total of 9,702 participants were analyzed in this study. This study indicated that in Pingtung, from 2011 to 2013, male, aged 65 years and those who have metabolic syndrome and its components are abnormal have lower eGFR. Multiple linear regression analysis was applied to examine the risk factors influencing eGFR. The results showed lower eGFR in males, participants aged 65 and over, participants with metabolic syndrome, blood pressure, waist circumference, and triglyceride level abnormalities.

  Conclusion: Predictors of eGFR decline included male gender, age of 65 years and over, metabolic syndrome, and abnormal blood pressure, waist circumference, and triglyceride levels.